Pellets are of great interest to the pharmaceutical industry for variety reasons, e.g. flexibility in dosage form design and drug efficacy improvement. Rotoagglomeration is the novel method for their production using rotoprocessors or rotogranulators allowing one-piece equipment operation. However this process is sensitive and includes numerous variables that have to be optimalized for successful result-spherical pellets of desired properties. This paper is contributing to study some of them: liquid amount, its spray rate and input powder amount and their influence on lactose-microcrystalline cellulose pellet properties.