Abstract
Krx-20, a zinc finger protein, plays an essential role in hindbrain segmentation of vertebrates. Zebrafish gene frb35 encodes a novel zinc finger protein that shares a high homology with Krx-20. The expression domains of frb35 overlap those of krx-20. The expression of frb35 first occurs in the 3rd rhombomere primordium at the onset of segmentation, which is soon followed by expression in the 5th rhombomere. From mid-segmentation onward, the 5th rhombomere has a higher frb35 expression level than the 3rd rhombomere. Unlike krx20, frb35 expression persists in the 5th rhombomere until the end of pharyngula period.
Copyright 2002 Elsevier Science Ireland Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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DNA, Complementary / metabolism
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DNA-Binding Proteins / biosynthesis*
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DNA-Binding Proteins / chemistry*
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Early Growth Response Protein 2
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Molecular Sequence Data
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Protein Structure, Tertiary
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Sequence Homology, Amino Acid
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Time Factors
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Transcription Factors / biosynthesis*
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Transcription Factors / chemistry*
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Transcription Factors / genetics
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Zebrafish
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Zebrafish Proteins / biosynthesis*
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Zebrafish Proteins / chemistry*
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Zebrafish Proteins / genetics
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Zinc Fingers*
Substances
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DNA, Complementary
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DNA-Binding Proteins
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Early Growth Response Protein 2
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Transcription Factors
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Zebrafish Proteins
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egr2a protein, zebrafish