Genetic basis for the origin of cardiac arrhythmias: implications for therapy

Mackenzi Mbai; Sridharan Rajamani; Brian P Delisle; Blake D Anson; Corey Anderson; Jonathan C Makielski; Craig T January

doi:10.1007/s11886-002-0041-5

Genetic basis for the origin of cardiac arrhythmias: implications for therapy

Curr Cardiol Rep. 2002 Sep;4(5):411-7. doi: 10.1007/s11886-002-0041-5.

Authors

Mackenzi Mbai¹, Sridharan Rajamani, Brian P Delisle, Blake D Anson, Corey Anderson, Jonathan C Makielski, Craig T January

Affiliation

¹ University of Wisconsin Hospitals and Clinics, Section of Cardiovascular Medicine, Room H6/354 CSC (3248), 600 Highland Avenue, Madison, WI 53792, USA.

PMID: 12169238
DOI: 10.1007/s11886-002-0041-5

Abstract

The recognition of the role that genetic abnormalities play in the generation of cardiac arrhythmias and sudden cardiac death has evolved enormously over the past decade. One result is new insight into underlying physiologic and pathophysiologic mechanisms. New therapies based on this evolving insight are being developed. This review summarizes recent discoveries with a focus on the genetic basis of cardiac arrhythmias and their implications for new therapies.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Arrhythmias, Cardiac / epidemiology
Arrhythmias, Cardiac / genetics*
Arrhythmias, Cardiac / therapy
Death, Sudden, Cardiac / epidemiology
Death, Sudden, Cardiac / etiology
Genetic Therapy
Humans
Risk Factors
United States / epidemiology

Grants and funding

R01 HL60723/HL/NHLBI NIH HHS/United States