Abstract
The human colon adenocarcinoma-derived cell line CaCo-2 male Swiss mice and male Sprague-Dawley rats were used as model systems to study the effects of nickel (II), 5-methyl-2-furaldehyde thiosemicarbazone ligand and their complex. The stimulation effect of the complex was obtained with low concentrations from 3.7 x 10(-7) to 3.7 x 10(-6) M, while inhibiting effects occurred from 3.7 x 10(-5) to 3.7 x 10(-4) M. This study showed that Ni (II) is toxic for cultured cells. Our data suggest that the comple; according to the toxicity assays in mice and carcinogenesis assays in rats, could be used as an antimitotic agent.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / toxicity
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Caco-2 Cells / drug effects
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Carcinogens
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Colonic Neoplasms / chemically induced
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Colonic Neoplasms / drug therapy
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Drug Screening Assays, Antitumor
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Humans
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Male
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Methylnitrosourea
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Mice
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Nickel / pharmacology*
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Nickel / toxicity
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Organometallic Compounds / pharmacology*
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Organometallic Compounds / toxicity
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Rats
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Rats, Sprague-Dawley
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Thiosemicarbazones / pharmacology*
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Thiosemicarbazones / toxicity
Substances
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Antineoplastic Agents
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Carcinogens
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Organometallic Compounds
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Thiosemicarbazones
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dichloro(5-methyl-2-furaldehyde thiosemicarbazone)nickel(II)
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Methylnitrosourea
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Nickel