Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine

Hye-Young H Kim; Markus Voehler; Thomas M Harris; Michael P Stone

doi:10.1021/ja020333r

Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine

J Am Chem Soc. 2002 Aug 14;124(32):9324-5. doi: 10.1021/ja020333r.

Authors

Hye-Young H Kim¹, Markus Voehler, Thomas M Harris, Michael P Stone

Affiliation

¹ Department of Chemistry, Center in Molecular Toxicology, Vanderbilt University, Nashville, Tennessee 37235, USA.

PMID: 12166998
DOI: 10.1021/ja020333r

Abstract

Spectroscopic evidence is presented for the formation of a carbinolamine interchain cross-link in 5'-CpG-3' sequences, arising from the acrolein adduct gamma-OH-PdG. This may be important in understanding biological processing of acrolein-induced DNA damage in CpG sequences.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Acrolein / chemistry*
CpG Islands*
DNA Adducts / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Purinones / chemistry*

Substances

DNA Adducts
Purinones
Acrolein

Abstract

Publication types

MeSH terms

Substances

Grants and funding