Arsenic carcinogenicity: relevance of c-Src activation

Mol Cell Biochem. 2002 May-Jun;234-235(1-2):277-82.

Abstract

Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.

Publication types

  • Review

MeSH terms

  • Arsenic / pharmacology*
  • Arsenic / toxicity*
  • Carcinogens / pharmacology*
  • Carcinogens / toxicity*
  • ErbB Receptors / metabolism
  • Gene Expression Regulation, Enzymologic / drug effects
  • Genes, src / genetics*
  • Humans
  • Mitogen-Activated Protein Kinases / metabolism
  • Oncogene Protein pp60(v-src) / genetics*
  • Oncogene Protein pp60(v-src) / metabolism*

Substances

  • Carcinogens
  • ErbB Receptors
  • Oncogene Protein pp60(v-src)
  • Mitogen-Activated Protein Kinases
  • Arsenic