Abstract
3,6-Ketals of 15-membered azalide pseudoaglycones are a novel series of macrolide antibiotics. The aromatic derivatives of the azalide 3,6-ketals demonstrated potent antibacterial activities against both Gram-positive and Gram-negative bacteria.
MeSH terms
-
Animals
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / pharmacology
-
Azithromycin / analogs & derivatives*
-
Female
-
Gram-Negative Bacteria / drug effects*
-
Gram-Positive Bacteria / drug effects*
-
Mastitis / drug therapy
-
Mice
-
Microbial Sensitivity Tests
-
Staphylococcus aureus / drug effects
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Azithromycin