Congenital estrogen deficiency in men: a new syndrome with different phenotypes; clinical and therapeutic implications in men

Mol Cell Endocrinol. 2002 Jul 31;193(1-2):19-28. doi: 10.1016/s0303-7207(02)00092-8.

Abstract

The report focuses on the role of estrogens in human male, dealing with two human models of congenital estrogen deficiency: estrogen resistance and aromatase deficiency. Similarities and differences of clinical phenotypes of these models are described and progresses of estrogen treatment of aromatase-deficient men are reported. Finally, the putative use of estrogen in men and the use of aromatase inhibitors and antiestrogen for male disorders are discussed.

Publication types

  • Review

MeSH terms

  • Aromatase / deficiency
  • Aromatase Inhibitors
  • Enzyme Inhibitors / therapeutic use
  • Estrogen Receptor alpha
  • Estrogens / deficiency*
  • Estrogens / physiology
  • Estrogens / therapeutic use
  • Growth Disorders / drug therapy
  • Humans
  • Male
  • Metabolism, Inborn Errors / drug therapy
  • Models, Biological
  • Phenotype
  • Receptors, Estrogen / deficiency
  • Syndrome

Substances

  • Aromatase Inhibitors
  • Enzyme Inhibitors
  • Estrogen Receptor alpha
  • Estrogens
  • Receptors, Estrogen
  • Aromatase