Fluoroscopy is an important diagnostic and interventional imaging tool that enables clinicians to view dynamic, real-time images of anatomy and function unmatched by other imaging techniques. However, operators must take into account many factors that impact the amount of radiation delivered, particularly over the course of a lengthy interventional procedure. After completing this review, readers will: Understand basic concepts of radiobiology and fluoroscopy systems. Know the typical doses and dose calculations for patients and fluoroscopic personnel. Recognize the pathology of biological effects and common radiation-induced skin injuries. Understand fluoroscopic technique factors to reduce patient exposure. Know the basic methods for controlling occupational exposure for fluoroscopic personnel.