Experience of treatment of 142 patients, operated on in clinic in 2001 yr for duodenal perforative ulcer was summarized. In 130 patients operation was performed by an open access method and in 12--by laparoscopic one. Laparoscopy was applied for the perforative aperture closure (in 5 patients) and for excision of ulcer with duodenoplasty (in 7). The operation duration have constituted (78 +/- 4.2) min at average. Postoperative complications were absent, all the patients survived. Duration of the patient treatment conducted in stationary after performance of laparoscopic operation have constituted (6.4 +/- 0.6) days at average and after application of open method--(9.6 +/- 5) days.