Novel alpha-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416. I. Taxonomy, fermentation and isolation

J Antibiot (Tokyo). 2002 May;55(5):457-61. doi: 10.7164/antibiotics.55.457.

Abstract

New alpha-glucosidase inhibitors, CKD-711 and CKD-711a were produced from the fermentation broth of Streptomyces sp. CK-4416 which was isolated from a forest soil of Jeju Island, South Korea. CKD-711 and CKD-711a were purified by Dowex 50W-2X and Sephadex G-10 column chromatography. In in vitro studies, CKD-711 showed a potent inhibitory activity against a-glucosidase from mammalian, but less inhibition against a-amylase from microorganism and mammalian. CKD-711a showed a lower inhibitory activity than CKD-711.

MeSH terms

  • Animals
  • Culture Media
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / metabolism
  • Fermentation
  • Glycoside Hydrolase Inhibitors*
  • Microscopy, Electron, Scanning
  • Rats
  • Soil Microbiology
  • Streptomyces / classification*
  • Streptomyces / growth & development
  • Streptomyces / metabolism*
  • alpha-Amylases / antagonists & inhibitors

Substances

  • Culture Media
  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • alpha-Amylases