Malignant melanoma is one of those malignancies with worldwide increasing incidence. The prognosis of malignant melanoma is bad because of its early hematogenous and lymphogenous metastases. Earliest possible diagnosis and sensitive follow-up of disease are important parameters to improve prognosis. In the literature a sensitivity of 92% and a specificity of 77% is found for blinded reading of F-18-FDG-PET of the whole body, and a specificity of 100% when clinical information was provided.