A new binding mode of competitive antagonists to metabotropic glutamate receptors exemplified by the mGluR1-receptor antagonist AIDA (RS-aminoindan-1,5-dicarboxylic acid)

Dokl Biochem Biophys. 2002 May-Jun:384:131-5. doi: 10.1023/a:1016076028063.

Authors

M S Belenikin¹, I I Baskin, V A Palyulin, N S Zefirov

Affiliation

¹ Moscow State University, Vorob'evy gory, Moscow, 119992 Russia.

PMID: 12134506
DOI: 10.1023/a:1016076028063

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding, Competitive
Indans / metabolism*
Indans / pharmacology*
Kinetics
Ligands
Models, Molecular
Molecular Conformation
Molecular Structure
Receptors, Metabotropic Glutamate / antagonists & inhibitors*
Receptors, Metabotropic Glutamate / chemistry
Receptors, Metabotropic Glutamate / metabolism*
Thermodynamics

Substances

1-aminoindan-1,5-dicarboxylic acid
Indans
Ligands
Receptors, Metabotropic Glutamate
metabotropic glutamate receptor type 1