Mild and highly selective formyl protection of primary hydroxyl groups

Lidia De Luca; Giampaolo Giacomelli; Andrea Porcheddu

doi:10.1021/jo0257492

Mild and highly selective formyl protection of primary hydroxyl groups

J Org Chem. 2002 Jul 26;67(15):5152-5. doi: 10.1021/jo0257492.

Authors

Lidia De Luca¹, Giampaolo Giacomelli, Andrea Porcheddu

Affiliation

¹ Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy.

PMID: 12126399
DOI: 10.1021/jo0257492

Abstract

Efficient conversion of primary alcohols to the corresponding formate esters can be carried out at room temperature in methylene chloride, using 2,4,6-trichloro-1,3,5-triazine and N,N-dimethylformamide in the presence of lithium fluoride. This procedure appears as a valid method for selectively protecting primary hydroxyl groups.