Abstract
Bicyclic azasugar glycomimetics related to castanospermine and trehazolin have been prepared from sugar carbodiimides via aminooxazoline intermediates; preliminary enzyme inhibition tests showed a marked dependence of the selectivity and potency towards alpha and beta-glucosidases upon the nature of the exocyclic substituent.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding, Competitive
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Disaccharides / chemical synthesis*
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Enzyme Inhibitors / chemical synthesis*
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Glycoside Hydrolase Inhibitors*
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Hydrogen-Ion Concentration
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Indolizines / chemical synthesis*
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Molecular Structure
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Plants / enzymology
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Trehalase / antagonists & inhibitors
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beta-Glucosidase / antagonists & inhibitors*
Substances
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Disaccharides
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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Indolizines
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trehazolin
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beta-Glucosidase
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Trehalase
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castanospermine