Synthesis of novel BINOL-derived chiral bisphosphorus ligands and their application in catalytic asymmetric hydrogenation

Chem Commun (Camb). 2002 May 21:(10):1124-5. doi: 10.1039/b201976k.

Abstract

Some novel ortho-substituted BINOL-derived bisphosphorous ligands (o-BINAPO and o-NAPHOS) were synthesis from readily available (S)-BINOL; these ligands showed excellent enantioselectivities (up to 99% ee) in Rh(I)-catalyzed asymmetric hydrogenation of functionalized olefins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Catalysis
  • Hydrogen / chemistry*
  • Ligands
  • Naphthols / chemical synthesis*
  • Naphthols / chemistry
  • Phosphorus Compounds / chemistry*
  • Stereoisomerism

Substances

  • BINOL, naphthol
  • Ligands
  • Naphthols
  • Phosphorus Compounds
  • Hydrogen