Abstract
The penetration of ampicillin and ciprofloxacin through biofilms formed by Klebsiella pneumoniae was confirmed by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm. Because the bacteria nevertheless survived antibiotic treatment, some protective mechanism other than inadequate penetration must have been at work in the biofilm.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Ampicillin / pharmacology
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Anti-Bacterial Agents / pharmacology*
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Anti-Infective Agents / pharmacology
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Biofilms / drug effects*
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Ciprofloxacin / pharmacology
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / ultrastructure*
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Microscopy, Electron
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Penicillins / pharmacology
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Ultraviolet Rays
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Penicillins
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Ciprofloxacin
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Ampicillin