Access to 2,5-disubstituted tetrahydrofurans from Grignard reagents and hemiacetal derivatives

Xavier Franck; Reynald Hocquemiller; Bruno Figadère

doi:10.1039/b109930m

Access to 2,5-disubstituted tetrahydrofurans from Grignard reagents and hemiacetal derivatives

Chem Commun (Camb). 2002 Jan 21:(2):160-1. doi: 10.1039/b109930m.

Authors

Xavier Franck¹, Reynald Hocquemiller, Bruno Figadère

Affiliation

¹ Laboratoire de Pharmacognosie, associé au CNRS (BIOCIS), Université Paris-Sud, Faculté de Pharmacie, rue Jean-Baptiste Clément 92296, Châtenay-Malabry, France.

PMID: 12120351
DOI: 10.1039/b109930m

Abstract

The first diastereoselective addition of Grignard reagents onto cyclic oxocarbenium ions, obtained from glycosyl acetates, to afford 2,5-disubstituted tetrahydrofurans, is reported.