Palladium-catalyzed cyclization of alkenyl beta-keto esters in the presence of chlorotrimethylsilane

Tao Pei; Ross A Widenhoefer

doi:10.1039/b111644d

Palladium-catalyzed cyclization of alkenyl beta-keto esters in the presence of chlorotrimethylsilane

Chem Commun (Camb). 2002 Mar 21:(6):650-1. doi: 10.1039/b111644d.

Authors

Tao Pei¹, Ross A Widenhoefer

Affiliation

¹ Duke University, P. M. Gross Chemical Laboratory, Durham, NC 27708-0346, USA.

PMID: 12120167
DOI: 10.1039/b111644d

Abstract

PdCl2(CH3CN)2 catalyzed the cyclization of alkenyl beta-keto esters in the presence of a stoichiometric amount of SiMe3Cl to form 2-carboalkoxycyclohexanones in good yield with excellent regioselectivity.