A new ergostanol saponin from Dioscorea deltoidea Wall var. orbiculata

J Asian Nat Prod Res. 2002 Sep;4(3):211-5. doi: 10.1080/10286020290024013.

Abstract

From the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculata, a novel ergostanol saponin, orbiculatoside A (1), was isolated and identified as 3-O-beta-D-glucopyranosyl-ergost-5-ene-3beta, 26-diol-26-O-beta-D-glucopyranosyl(1-->3)-[beta-D-glucopyranosyl(1-->2)-beta-D-glucupyranosyl(1-->6)]-beta-D-glucopyranoside by various NMR techniques in combination with chemical methods. The new saponin showed strong activity against Pyricularia oryzae, with a MMDC (minimum morphological deformation concentration) value of 28.04 micromol/l and was cytotoxic to cancer cell line K562, HCT-15, A549, HT1080, and A2780a in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Dioscorea*
  • Ergosterol / analogs & derivatives*
  • Ergosterol / chemistry
  • Ergosterol / isolation & purification
  • Humans
  • Inhibitory Concentration 50
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rhizome
  • Saponins / chemistry
  • Saponins / isolation & purification
  • Saponins / pharmacology*
  • Saponins / therapeutic use
  • Tumor Cells, Cultured / drug effects

Substances

  • Antineoplastic Agents
  • Plant Extracts
  • Saponins
  • orbiculatoside A
  • ergostanol
  • Ergosterol