A clinical study of the concept "wide-focus and low-pressure" extracorporal shock-wave lithotripsy (ESWL) was performed in a scientific cooperation between the Physical Institute of the University of Stuttgart and the Xixin Medical Instruments Co. Ltd. in Wuxian-Suzhou, China. In this cooperation, self-focusing electromagnetic shock-wave generator systems from the University of Stuttgart were integrated into Xixin lithotripters and installed in seven hospitals in China. A total of 297 detailed patient protocols revealed an average of 1532 shock pulses for successful treatment with no necessity for pain medication and auxiliary measures, and a stone-free rate of 86% after a follow-up of 3 months. These results are discussed in terms of the wide-focus low-pressure conditions and the mechanism of binary fragmentation by squeezing.