ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum

Phytother Res. 2002 Jun;16(4):387-8. doi: 10.1002/ptr.955.

Abstract

Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC(50) = 4.8 microg/mL) and KB cells (IC(50) = 1.6 microg/mL).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Apiaceae / chemistry*
  • Artemia / drug effects
  • Artemia / physiology
  • Carcinoma, Squamous Cell / pathology
  • Cytotoxins / chemistry
  • Cytotoxins / pharmacology*
  • Diterpenes / chemistry
  • Diterpenes / pharmacology*
  • Humans
  • Inhibitory Concentration 50
  • KB Cells
  • Lethal Dose 50
  • Molecular Structure

Substances

  • Antineoplastic Agents, Phytogenic
  • Cytotoxins
  • Diterpenes
  • argyrophilic acid