Can MMTV exploit TLR4?

Trends Microbiol. 2002 Jul;10(7):303-5; discussion 305-6. doi: 10.1016/s0966-842x(02)02385-5.

Abstract

The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response. A recent publication proposed that the retrovirus mouse mammary tumor virus exploits the pattern-recognition receptor Toll-like receptor 4 to achieve more efficient infection.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / virology
  • Drosophila Proteins*
  • Mammary Tumor Virus, Mouse / immunology*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / immunology*
  • Mice
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / immunology*
  • Toll-Like Receptor 4
  • Toll-Like Receptors
  • Viral Envelope Proteins / immunology

Substances

  • Drosophila Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptor 4
  • Toll-Like Receptors
  • Viral Envelope Proteins