Abstract
Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / genetics
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Alzheimer Disease / metabolism
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Alzheimer Disease / physiopathology*
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Animals
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Brain / metabolism
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Brain / pathology
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Brain / physiopathology*
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Disease Models, Animal
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Humans
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Microtubules / metabolism
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Microtubules / pathology
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Microtubules / physiology
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Neurofibrillary Tangles / genetics
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Neurofibrillary Tangles / pathology
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Neurons / metabolism*
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Neurons / pathology
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Neurons / physiology*
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tau Proteins / genetics
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tau Proteins / metabolism*
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tau Proteins / physiology*