Abstract
Lipoic acid is a prostetic group of H-protein of the glycine cleavage system and the dihydrolipoamide acyltransferases (E2) of the pyruvate, alpha-ketoglutarate and branched-chain alpha-keto acid dehydrogenase complexes. Lipoic acid and its reduced form, dihydrolipoic acid, reacts with oxygen reactive species. This paper reviews the beneficial effects in oxidative stress models or clinical conditions.
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy
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Aging / drug effects
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Animals
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Antioxidants / metabolism
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Cataract / drug therapy
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Decarboxylation
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Diabetic Angiopathies / drug therapy
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Diabetic Neuropathies / drug therapy
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Glycine / metabolism
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Humans
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Liver Diseases / drug therapy
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Metals / poisoning
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Neurodegenerative Diseases / drug therapy
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Oxidative Stress / physiology
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Physical Exertion / physiology
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Thioctic Acid / metabolism*
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Thioctic Acid / therapeutic use
Substances
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Antioxidants
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Metals
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Thioctic Acid
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Glycine