[Biologic properties of lipoic acid]

Postepy Hig Med Dosw. 2002;56(2):201-19.
[Article in Polish]

Abstract

Lipoic acid is a prostetic group of H-protein of the glycine cleavage system and the dihydrolipoamide acyltransferases (E2) of the pyruvate, alpha-ketoglutarate and branched-chain alpha-keto acid dehydrogenase complexes. Lipoic acid and its reduced form, dihydrolipoic acid, reacts with oxygen reactive species. This paper reviews the beneficial effects in oxidative stress models or clinical conditions.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy
  • Aging / drug effects
  • Animals
  • Antioxidants / metabolism
  • Cataract / drug therapy
  • Decarboxylation
  • Diabetic Angiopathies / drug therapy
  • Diabetic Neuropathies / drug therapy
  • Glycine / metabolism
  • Humans
  • Liver Diseases / drug therapy
  • Metals / poisoning
  • Neurodegenerative Diseases / drug therapy
  • Oxidative Stress / physiology
  • Physical Exertion / physiology
  • Thioctic Acid / metabolism*
  • Thioctic Acid / therapeutic use

Substances

  • Antioxidants
  • Metals
  • Thioctic Acid
  • Glycine