Mycobacterial lipoarabinomannans: modulators of dendritic cell function and the apoptotic response

Microbes Infect. 2002 Jul;4(9):945-53. doi: 10.1016/s1286-4579(02)01621-0.

Abstract

The molecular bases of Mycobacterium tuberculosis pathogenicity remain unclear. We report here how M. tuberculosis mannosylated lipoarabinomannans contribute to the survival of bacilli in the human reservoir by (i) inhibiting IL-12 production by macrophages and dendritic cells and (ii) modulating M. tuberculosis-induced macrophage apoptosis.

Publication types

  • Review

MeSH terms

  • Antigens, Bacterial / immunology*
  • Apoptosis*
  • Cytokines / biosynthesis
  • Cytokines / immunology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Humans
  • Lipopolysaccharides / chemistry
  • Lipopolysaccharides / immunology*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mycobacterium tuberculosis / immunology*
  • Receptors, Cell Surface / metabolism
  • Signal Transduction
  • Tuberculosis / immunology*

Substances

  • Antigens, Bacterial
  • Cytokines
  • Lipopolysaccharides
  • Receptors, Cell Surface
  • lipoarabinomannan