This paper summarizes the "Agrochemical and Nutrient Impacts on Estuaries" symposium held at the 220th National Meeting of the American Chemical Society. The focus of the symposium was to highlight ongoing research efforts to understand estuarine function and pollutant fate in these important ecosystems. Expanding urbanization and agricultural activity can result in increased particulate and chemical loads, resulting in decreased light penetration and degraded aquatic habitats. Legislative and regulatory protections, such as the Clean Water Act and Total Maximum Daily Loads (TMDLs), are considered here. Measurement of nutrient and pesticide loads and their ecotoxicological impacts are explored, as well as potential mitigation practices. The complexity and high visibility of estuarine ecosystem health will require continued examination to develop more effective agricultural and land management strategies and sound science-based regulations.