The introduction of multislice CT was a breakthrough with regard to increased scan speed, improved axial resolution and better utilization of the tube output. The new generation of multislice CT scanners offering simultaneous acquisition of up to 16 sub-millimeter slices represents an important leap on the way towards true isotropic scanning. We present an evaluation of a state-of-the-art 16-slice CT system (SOMATOM Sensation 16, Siemens AG, Forchheim, Germany). After an introduction to the detector design we discuss dose utilization and finally elaborate on multislice spiral scanning with 16 slices. Due to the increased number of slices dose utilization is improved compared to current 4-slice CT scanners, and sub-millimeter collimation needs no longer be restricted to special applications. For CT systems with 8 or more slices, the cone-beam geometry causes severe artifacts if not corrected for by a so-called cone-correction, which thus becomes mandatory in this case. With the Adaptive Multiple Plane Reconstruction AMPR, cone beam artifacts are effectively suppressed, while the benefits of Adaptive Axial Interpolation are maintained: free selection of the spiral pitch according to the clinical needs of an examination, slice width independent of the pitch, full dose utilization at all pitch values. Clinical practice will have to demonstrate the application spectrum that is opened with the new generation of multislice CT systems.