Iroquois genes: genomic organization and function in vertebrate neural development

José Luis Gómez-Skarmeta; Juan Modolell

doi:10.1016/s0959-437x(02)00317-9

Iroquois genes: genomic organization and function in vertebrate neural development

Curr Opin Genet Dev. 2002 Aug;12(4):403-8. doi: 10.1016/s0959-437x(02)00317-9.

Authors

José Luis Gómez-Skarmeta¹, Juan Modolell

Affiliation

¹ Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. jlgomez@cbm.uam.es

PMID: 12100884
DOI: 10.1016/s0959-437x(02)00317-9

Abstract

We review recent work that shows that the iroquois (Iro/Irx) homeobox genes have conserved genomic organization in Drosophila and vertebrates. In addition, these genes play pivotal functions in the initial specification of the vertebrate neuroectoderm, and, in collaboration with other transcription factors, later subdivision of the anterior-posterior and dorso-ventral axis of the neuroectoderm.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Evolution, Molecular
Gene Duplication
Homeodomain Proteins / genetics*
Homeodomain Proteins / physiology
Multigene Family
Nervous System / embryology*
Transcription Factors / genetics*
Transcription Factors / physiology
Vertebrates / embryology
Vertebrates / genetics*
Vertebrates / physiology

Substances

Homeodomain Proteins
Transcription Factors