Abstract
Photoperiod was hypothesized to mediate T cell-dependent B cell production of IgM and IgG. Antigens induced production of specific immunoglobulins; serum IgM but not IgG, was higher in males in long vs. short days (16 vs. 8 h light/day) and similarly among all groups of females. A second immunization with KLH robustly enhanced serum IgM, as well as IgG; increases were blunted in short- vs. long-day males but not in females. Thus, in male but not female hamsters, winter-like short days restrain aspects of primary and secondary humoral immune responses to xenoantigens. Actions on lymphocyte activities or clonal expansion are in considerations.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibody Formation / drug effects
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Antibody Formation / immunology*
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Antigens / immunology
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Antigens / pharmacology
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B-Lymphocytes / drug effects
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B-Lymphocytes / immunology
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Carrier Proteins / immunology
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Carrier Proteins / pharmacology
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Circadian Rhythm / drug effects
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Circadian Rhythm / immunology*
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Cricetinae
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Female
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Hemocyanins / immunology
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Hemocyanins / pharmacology
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Immunoglobulin G / biosynthesis
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Immunoglobulin G / blood
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Immunoglobulin G / drug effects
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Immunoglobulin M / biosynthesis
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Immunoglobulin M / blood
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Immunoglobulin M / drug effects
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Immunoglobulins / biosynthesis*
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Immunoglobulins / drug effects
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Immunoglobulins / immunology
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Intracellular Signaling Peptides and Proteins*
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Male
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Neuroimmunomodulation / drug effects
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Neuroimmunomodulation / immunology*
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Phodopus
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Photoperiod*
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Seasons*
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Sex Characteristics*
Substances
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Antigens
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Carrier Proteins
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Cavin3 protein, rat
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Immunoglobulin G
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Immunoglobulin M
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Immunoglobulins
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Intracellular Signaling Peptides and Proteins
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Hemocyanins
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keyhole-limpet hemocyanin