The outcome of autologous chondrocyte transplantation treatment of cartilage lesions in the knee

Matej Drobnic; Nevenka Kregar-Velikonja; Damjan Radosavljevic; Miro Gorensek; Branko Koritnik; Elvira Malicev; Gordana Wozniak; Matjaz Jeras; Miomir Knezevic

The outcome of autologous chondrocyte transplantation treatment of cartilage lesions in the knee

Cell Mol Biol Lett. 2002;7(2):361-3.

Authors

Matej Drobnic¹, Nevenka Kregar-Velikonja, Damjan Radosavljevic, Miro Gorensek, Branko Koritnik, Elvira Malicev, Gordana Wozniak, Matjaz Jeras, Miomir Knezevic

Affiliation

¹ Department of Orthopaedic Surgery, Clinical Centre, Zaloska 9, SI-1000 Ljubljana, Slovenia.

PMID: 12097986

Abstract

Recent results of the clinical outcome of autologous chondrocyte transplantation (ACT) treatment in a group of 28 patients with focal femoral condyle cartilage lesions revealed a correlation trend with the quality of the in vitro cell culture matrix-protein synthesis. No impact of the patients' age and chondrocyte cryopreservation prior to implantation was observed. Further studies are needed to confirm the preliminary results.

MeSH terms

Adolescent
Adult
Age Factors
Aggrecans
Cartilage, Articular / cytology
Cell Transplantation
Chondrocytes / transplantation*
Collagen Type I / analysis
Collagen Type II / analysis
Extracellular Matrix Proteins*
Humans
Knee
Lectins, C-Type
Middle Aged
Proteoglycans / analysis
Transplantation, Autologous
Treatment Outcome

Substances

Aggrecans
Collagen Type I
Collagen Type II
Extracellular Matrix Proteins
Lectins, C-Type
Proteoglycans