[The "air pouch" model in mice and a study of the wound fluid proteolytic activity]

I V Voronkina; A M Kharisov; M I Blinova; I L Potokin; B A Paramonov; G P Pinaev

[The "air pouch" model in mice and a study of the wound fluid proteolytic activity]

Tsitologiia. 2002;44(3):270-6.

[Article in Russian]

Authors

I V Voronkina¹, A M Kharisov, M I Blinova, I L Potokin, B A Paramonov, G P Pinaev

Affiliation

¹ Institute of Cytology RAS, St. Petersburg. voron@link.cytspb.rssi.ru

PMID: 12094765

Abstract

The experimental model of a cutaneous wound in mice has been offered, aimed to study the proteolytic activity of the wound fluid produced at early stages of wound healing, and to examine the continuous inflammatory state. The presence of metalloproteinases MMP-2 and MMP-9 in the wound fluid matrix was found to correlate with the existence of neutrophils and macrophages in the tissue.

Publication types

English Abstract

MeSH terms

Animals
Carrageenan
Dermatitis / etiology
Dermatitis / immunology
Dermatitis / metabolism
Disease Models, Animal*
Exudates and Transudates / enzymology
Exudates and Transudates / immunology
Exudates and Transudates / metabolism*
Macrophages / immunology
Matrix Metalloproteinase 2 / analysis
Matrix Metalloproteinase 2 / metabolism
Matrix Metalloproteinase 9 / analysis
Matrix Metalloproteinase 9 / metabolism
Mice
Mice, Inbred BALB C
Neutrophils / immunology
Skin / immunology
Skin / injuries*
Skin / metabolism
Wound Healing*

Substances

Carrageenan
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9