While only a few of the mucocutaneous disorders are presented here, many others exist. Often the dental team will be the first to observe clinical signs of mucocutaneous disorders, and therefore it is prudent to ask about eye, skin, and genital lesions, as patients may not often volunteer this information. In the case of Pemphigus, dentists can play a key role in early detection of a potentially fatal disorder. In cases where chronic gingival inflammation remains despite local measures and good patient oral hygiene, it may be wise to include a mucocutaneous disorder in the differential diagnosis.