Polymer-supported ferrocenyl oxazolines for the catalyzed highly enantioselective phenyl transfer to aldehydes

Bioorg Med Chem Lett. 2002 Jul 22;12(14):1795-8. doi: 10.1016/s0960-894x(02)00271-8.

Abstract

A new chiral MeO-PEG-supported ferrocenyl oxazoline was synthesized and successfully employed in the enantioselective phenyl transfer to aldehydes. The products were obtained in high yields and with excellent enantioselectivities (up to 97% ee). Furthermore, the recovery of the ferrocene was facile, and catalyst efficiency was maintained in subsequent reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzaldehydes / chemistry*
  • Benzhydryl Compounds / chemistry*
  • Catalysis
  • Ferrous Compounds / chemical synthesis*
  • Ferrous Compounds / chemistry
  • Metallocenes
  • Oxazolone / analogs & derivatives*
  • Oxazolone / chemical synthesis*
  • Polymers / chemistry
  • Stereoisomerism
  • Zinc / chemistry

Substances

  • Benzaldehydes
  • Benzhydryl Compounds
  • Ferrous Compounds
  • Metallocenes
  • Polymers
  • trifluoromethyloxazolinone
  • Oxazolone
  • Zinc
  • ferrocene