Accelerated and improved osteointegration of implants biocoated with bone morphogenetic protein 2 (BMP-2)

Herbert P Jennissen

doi:10.1111/j.1749-6632.2002.tb03067.x

Accelerated and improved osteointegration of implants biocoated with bone morphogenetic protein 2 (BMP-2)

Ann N Y Acad Sci. 2002 Jun:961:139-42. doi: 10.1111/j.1749-6632.2002.tb03067.x.

Author

Herbert P Jennissen¹

Affiliation

¹ Institute of Physiological Chemistry, University of Essen, Hufelandstrasse 55, D-45122 Essen, Germany. hp.jennissen@uni-essen.de

PMID: 12081883
DOI: 10.1111/j.1749-6632.2002.tb03067.x

Abstract

A concept and methodology are presented for the direct biocoating of implantable metals like titanium and stainless steel with bone morphogenetic protein 2 (BMP-2) for future applications as cementless bone or dental prostheses. Such bioactive surfaces can influence cells and tissues by chemotactic as well as juxtacrine mechanisms. Reference is made to first experiments in sheep and rabbits in which BMP-2 coatings impressively increased the osteoinductive potential of titanium implants.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biocompatible Materials / pharmacology*
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins / pharmacology*
Bone and Bones / cytology
Humans
Recombinant Proteins / pharmacology
Sheep
Tissue Engineering / methods*
Titanium / pharmacology
Transforming Growth Factor beta*

Substances

BMP2 protein, human
Biocompatible Materials
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Recombinant Proteins
Transforming Growth Factor beta
recombinant human bone morphogenetic protein-2
Titanium