Abstract
[reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Fungi / chemistry
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Molecular Mimicry
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Pyridones / chemical synthesis*
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Pyridones / chemistry
Substances
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Enzyme Inhibitors
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Pyridones
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pyridomacrolidin
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pyridovericin
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Protein-Tyrosine Kinases