Total synthesis of pyridovericin: studies toward the biomimetic synthesis of pyridomacrolidin

Org Lett. 2002 Jun 27;4(13):2125-7. doi: 10.1021/ol0200504.

Abstract

[reaction: see text] The total synthesis of the novel metabolite pyridovericin 1 is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Fungi / chemistry
  • Molecular Mimicry
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Pyridones / chemical synthesis*
  • Pyridones / chemistry

Substances

  • Enzyme Inhibitors
  • Pyridones
  • pyridomacrolidin
  • pyridovericin
  • Protein-Tyrosine Kinases