Malignant oedema is a fatal disease of several animal species, produced by one or more members of the Clostridium genus. We report here a case of malignant oedema in a 1-year-old Friesian sheep after a blood sample was collected from the jugular vein. Clostridium septicum and Clostridium sordellii were isolated from the lesions and also demonstrated by a fluorescent antibody test. This report stresses the need for maintaining a clean environment for animals and for strict hygienic measures during procedures that generate wounds, together with immunity acquired by proper vaccination, for prevention of malignant oedema.