Abstract
Diacylglyceride kinases, sphingosine kinases, NAD kinases and 6-phosphofructokinases are thought to be related despite large evolution of their sequences. Discovery of a common signature has led to the suggestion that they possess a similar phosphate-donor-binding site and a similar phosphorylation mechanism. The substrate- and allosteric-binding sites are much more divergent and their delineation remains to be determined experimentally.
MeSH terms
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Allosteric Site
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Amino Acid Motifs
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Amino Acid Sequence
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Diacylglycerol Kinase / chemistry*
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Diacylglycerol Kinase / metabolism
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Molecular Sequence Data
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Phosphofructokinase-1 / chemistry*
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Phosphofructokinase-1 / metabolism
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Phosphorylation
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Phosphotransferases (Alcohol Group Acceptor) / chemistry*
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
Substances
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Phosphotransferases (Alcohol Group Acceptor)
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sphingosine kinase
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Diacylglycerol Kinase
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Phosphofructokinase-1
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NAD kinase