Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives

José M Bueno; Jesús Chicharro; José M Fiandor; Federico Gómez de las Heras; Sophie Huss

doi:10.1016/s0960-894x(02)00293-7

Antifungal Sordarins. Part 4: synthesis and structure--activity relationships of 3',4'-fused alkyl-tetrahydrofuran derivatives

Bioorg Med Chem Lett. 2002 Jul 8;12(13):1697-700. doi: 10.1016/s0960-894x(02)00293-7.

Authors

José M Bueno¹, Jesús Chicharro, José M Fiandor, Federico Gómez de las Heras, Sophie Huss

Affiliation

¹ GlaxoSmithkline, Research Department, Parque Tecnológico de Madrid, Severo Ochoa, 2.28760 Tres Cantos, Madrid, Spain.

PMID: 12067540
DOI: 10.1016/s0960-894x(02)00293-7

Abstract

A series of Sordarin derivatives bearing alkyl substituted tetrahydrofuran rings fused to C3'-C4' bond of the sugar moiety have been prepared and their antifungal properties evaluated. Most of them show remarkable antifungal activity against Candida spp and Cryptococcus neoformans.

MeSH terms

Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry*
Antifungal Agents / pharmacology*
Fluconazole / pharmacology
Furans / chemical synthesis*
Furans / chemistry
Furans / pharmacology*
Indenes
Microbial Sensitivity Tests
Structure-Activity Relationship

Substances

Antifungal Agents
Furans
GM193663
Indenes
sordarin
tetrahydrofuran
Fluconazole