Abstract
Plants recognize many pathogens through the action of a diverse family of proteins called disease resistance (R) genes. The Arabidopsis R gene RPM1 encodes resistance to specific Pseudomonas syringae strains. We describe an RPM1-interacting protein that is an ortholog of TIP49a, previously shown to interact with the TATA binding protein (TBP) complex and to modulate c-myc- and beta-catenin-mediated signaling in animals. Reduction of Arabidopsis TIP49a (AtTIP49a) mRNA levels results in measurable increases of two R-dependent responses without constitutively activating defense responses, suggesting that AtTIP49a can act as a negative regulator of at least some R functions. Further, AtTIP49a is essential for both sporophyte and female gametophyte viability. Thus, regulators of R function overlap with essential modulators of plant development.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Arabidopsis / embryology*
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Arabidopsis / genetics
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Arabidopsis Proteins / genetics
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Arabidopsis Proteins / metabolism*
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Clone Cells
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Conserved Sequence
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DNA Helicases
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Evolution, Molecular
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Gene Deletion
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Gene Expression Regulation
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Genes, Plant
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Immunity, Innate / genetics*
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Plant Diseases / genetics*
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Plant Proteins / metabolism
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Pseudomonas / pathogenicity
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Recombinant Fusion Proteins / isolation & purification
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Recombinant Fusion Proteins / metabolism
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Suppression, Genetic
Substances
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Arabidopsis Proteins
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Carrier Proteins
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Plant Proteins
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RNA, Messenger
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RPM1 protein, Arabidopsis
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Recombinant Fusion Proteins
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DNA Helicases
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TIP49a protein, Arabidopsis