The WHO Healthy Cities Project has been developed in Europe to place health high on the agenda of city decision-makers. It has promoted comprehensive local strategies for health and sustainable development. Cities endorse principles and strategies, establish project infrastructures, work on specific goals, products, changes, and outcomes, and invest in formal and informal networking and cooperation. Consistent research and development efforts are contributing towards a more evidence-based policy making and to the emergence of a framework to meet the demands of the new public health movement.