Influence of processing conditions in the manufacture of O/W creams: I. Effect on dispersion grade and rheological characteristics

Farmaco. 2002 May;57(5):341-7. doi: 10.1016/s0014-827x(02)01213-2.

Abstract

Two series of O/W creams having the same general formulation were prepared in three different mechanical conditions (F with an hand blender; S with a turbomixer; T with a vacuum turbo emulsor) using two types of surfactants, polyoxyethylene-cetostearyl alcohols and polyglyceryl-3-methylglucose-distearate. By means of microscopic image analysis it was possible to point out the dispersion grade of the oil internal phase increasing with the energy applied under the conditions of manufacture (F < S < T). The level of dispersion influenced significantly on the rheological characteristics of the creams. With polyoxyethylene-cetostearyl alcohols, the viscosity of creams increased as the energy applied in manufacturing increased, with polyglyceryl-3-methylglucose-distearate on the contrary decreased. Moreover, indifferently to the manufacturing conditions, even in the same concentration of surfactant, the creams obtained with the last produced a much greater viscosity. At a parity of manufacturing conditions the differences between the batches of productions were not significant.

Publication types

  • Comparative Study

MeSH terms

  • Centrifugation
  • Chemistry, Pharmaceutical / methods*
  • Drug Industry
  • Drug Stability
  • Emulsions / chemistry*
  • Fatty Alcohols / chemistry*
  • Glycerides / chemistry*
  • Microscopy
  • Oils / analysis
  • Oils / chemistry
  • Rheology / methods
  • Stearates / chemistry*
  • Surface-Active Agents / chemistry
  • Time Factors
  • Viscosity
  • Water / chemistry

Substances

  • Emulsions
  • Fatty Alcohols
  • Glycerides
  • Oils
  • Stearates
  • Surface-Active Agents
  • polyglyceryl-3-methylglucose-distearate
  • Water