Alpha,beta-unsaturated 4-oxo acids in heterocylic synthesis. II. Behavior of 3-(1,1-dioxadibenzothein-4-oyl)acrylic acid towards carbon nucleophiles under Michael reaction condition

A A F Wasfy; M S Amine; M M H Arief; S G Donia; A A Aly

doi:10.1007/BF02817670

Alpha,beta-unsaturated 4-oxo acids in heterocylic synthesis. II. Behavior of 3-(1,1-dioxadibenzothein-4-oyl)acrylic acid towards carbon nucleophiles under Michael reaction condition

Folia Microbiol (Praha). 2002;47(2):131-6. doi: 10.1007/BF02817670.

Authors

A A F Wasfy¹, M S Amine, M M H Arief, S G Donia, A A Aly

Affiliation

¹ Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.

PMID: 12058390
DOI: 10.1007/BF02817670

Abstract

3-(1,1-Dioxadibenzothien-4-oyl)acrylic acid (1) was condensed with compounds containing active methylene groups under Michael reaction conditions to furnish the Michael adducts (lactones 2a-c, lactams 3a-c, ketones 4a,b). The behavior of these adducts toward the action of hydrazine hydrate were investigated. The compounds were tested for their biological properties.

MeSH terms

Acrylates / chemical synthesis*
Acrylates / chemistry
Acrylates / pharmacology*
Bacteria / drug effects
Carboxylic Acids / chemical synthesis*
Carboxylic Acids / chemistry
Carboxylic Acids / pharmacology
Microbial Sensitivity Tests
Spectrum Analysis

Substances

Acrylates
Carboxylic Acids
acrylic acid