Bilateral calcified ovarian fibromas in a patient with Sotos syndrome

Fertil Steril. 2002 Jun;77(6):1285-7. doi: 10.1016/s0015-0282(02)03118-7.

Abstract

Objective: To present a case of bilateral calcified ovarian fibromas in Sotos syndrome (cerebral gigantism).

Design: Descriptive case study.

Setting: Mackay Memorial Hospital.

Patient(s): A 26-year-old woman with Sotos syndrome and bilateral solid adnexal masses on gynecologic ultrasound.

Intervention(s): Surgical removal of an 8 x 6 x 6 cm left ovarian fibroma and a 3 x 2 x 2 cm right ovarian fibroma.

Main outcome measure(s): Ultrasound.

Result(s): Histopathologic examination revealed bilateral ovarian fibromas with extensive foci of calcification and occasional ossification.

Conclusion(s): The presence of bilateral calcified ovarian fibromas in this patient with Sotos syndrome may reflect the effects of overgrowth in Sotos syndrome on ovarian tumorigenesis or may be a coincidence.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple*
  • Adult
  • Brain / abnormalities*
  • Calcinosis / complications*
  • Calcinosis / pathology
  • Calcinosis / surgery
  • Craniofacial Abnormalities / complications*
  • Female
  • Humans
  • Leiomyoma / complications*
  • Leiomyoma / pathology
  • Leiomyoma / surgery
  • Ossification, Heterotopic / complications
  • Ossification, Heterotopic / pathology
  • Ovarian Neoplasms / complications*
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery
  • Syndrome