Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

Bioorg Med Chem. 2002 Aug;10(8):2439-44. doi: 10.1016/s0968-0896(02)00116-5.

Abstract

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

Publication types

  • Duplicate Publication
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / chemical synthesis*
  • Angiogenesis Inhibitors / pharmacology
  • Animals
  • Cattle
  • Cell Division / drug effects
  • Chick Embryo
  • Curcumin / analogs & derivatives*
  • Curcumin / chemical synthesis*
  • Curcumin / pharmacology
  • Dose-Response Relationship, Drug
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects*
  • Hydrazines / chemical synthesis*
  • Hydrazines / pharmacology
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Neovascularization, Physiologic / drug effects

Substances

  • Angiogenesis Inhibitors
  • Hydrazines
  • hydrazinocurcumin
  • Curcumin