Cloning and molecular characterization of the cDNA encoding histone H1 from Leishmania braziliensis

E Martínez; M C Thomas; V Alonso; E Carmelo; A C González; A Del Castillo; B Valladares

doi:10.1645/0022-3395(2002)088[0199:CAMCOT]2.0.CO;2

Cloning and molecular characterization of the cDNA encoding histone H1 from Leishmania braziliensis

J Parasitol. 2002 Feb;88(1):199-203. doi: 10.1645/0022-3395(2002)088[0199:CAMCOT]2.0.CO;2.

Authors

E Martínez¹, M C Thomas, V Alonso, E Carmelo, A C González, A Del Castillo, B Valladares

Affiliation

¹ Departamento de Parasitología, Ecología y Genética, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.

PMID: 12053969
DOI: 10.1645/0022-3395(2002)088[0199:CAMCOT]2.0.CO;2

Abstract

The isolation and molecular characterization of the histone H1-encoding gene from Leishmania braziliensis was carried out. The gene is present in the genome as a single copy and transcribed as a polyadenylated transcript of 830 nucleotides. The deduced amino acid sequence has in its central region the DNA binding K-[K/R]-A-A-[A/P] motif, which is repeated in tandem 9 times.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular / methods*
DNA, Complementary / genetics
DNA, Protozoan / analysis
DNA, Protozoan / genetics
Histones / chemistry
Histones / genetics*
Histones / metabolism
Leishmania braziliensis / genetics*
Molecular Sequence Data
Sequence Analysis, DNA

Substances

DNA, Complementary
DNA, Protozoan
Histones

Associated data

GENBANK/AF131892