The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children

Eur J Immunogenet. 2002 Jun;29(3):219-22. doi: 10.1046/j.1365-2370.2002.00292.x.

Abstract

We investigated the association of the CTLA4 +49 A/G dimorphism with type 1 diabetes in Czech children. Genotyping of 305 diabetic children and 289 controls by a novel PCR-ARMS assay revealed no significant differences in the genotypic or allelic frequencies. This may be another piece of evidence against the +49 A/G transition as the aetiological polymorphism within the CTLA4 gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antigens, CD
  • Antigens, Differentiation / genetics*
  • CTLA-4 Antigen
  • Case-Control Studies
  • Child
  • Czech Republic
  • Diabetes Mellitus, Type 1 / genetics*
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Phenotype
  • Polymorphism, Single Nucleotide*

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • CTLA4 protein, human