[Construction and study of antigenic characteristics of recombinant salmonella strain producing TBI protein]

Vopr Virusol. 2002 Mar-Apr;47(2):25-8.
[Article in Russian]

Abstract

A recombinant strain producing TBI protein (artificial protein containing HIV-1 B and T cell epitopes) was constructed on the base of attenuated Salmonella typhimurium SL7207 strain and BALB/c mice were immunized with this strain in a dose of 10(9) live cells orally or rectally. A single immunization with the recombinant salmonella strain induced humoral and cellular immune response to HIV-1; hence, this strain is a promising candidate for vaccine against HIV.

Publication types

  • English Abstract

MeSH terms

  • AIDS Vaccines / administration & dosage
  • AIDS Vaccines / biosynthesis
  • AIDS Vaccines / immunology*
  • Administration, Oral
  • Administration, Rectal
  • Animals
  • Antibodies, Viral / analysis
  • Antibody Formation
  • Genes, Synthetic*
  • HIV Infections / immunology
  • HIV Infections / prevention & control
  • HIV-1 / immunology*
  • Immunity, Cellular
  • Immunoenzyme Techniques
  • Mice
  • Mice, Inbred BALB C
  • Protein Biosynthesis
  • Proteins / genetics
  • Proteins / immunology*
  • Recombinant Proteins / biosynthesis
  • Recombination, Genetic
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / immunology*
  • Spleen / immunology
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / biosynthesis
  • Vaccines, Synthetic / immunology

Substances

  • AIDS Vaccines
  • Antibodies, Viral
  • Proteins
  • Recombinant Proteins
  • TBI protein, recombinant
  • Vaccines, Synthetic