Lembehsterols A and B, novel sulfated sterols inhibiting thymidine phosphorylase, from the marine sponge Petrosia strongylata

Chem Pharm Bull (Tokyo). 2002 Jun;50(6):827-30. doi: 10.1248/cpb.50.827.

Abstract

Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the basis of chemical and physicochemical evidence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Marine Biology
  • Porifera / enzymology*
  • Sterols / chemistry
  • Sterols / isolation & purification
  • Sterols / pharmacology*
  • Thymidine Phosphorylase / antagonists & inhibitors*
  • Thymidine Phosphorylase / metabolism

Substances

  • Enzyme Inhibitors
  • Sterols
  • lembehsterol A
  • lembehsterol B
  • Thymidine Phosphorylase