New taxane diterpenoids from the roots of Taiwanese Taxus mairei

Chem Pharm Bull (Tokyo). 2002 Jun;50(6):781-7. doi: 10.1248/cpb.50.781.

Abstract

Five new taxane diterpenoids, taxumairols G (1), H (2), I (3), J (4), and L (5) were isolated from extracts of the roots of Taiwanese Taxus mairei (LEMEE & LEVL.) S. Y. Hu. Compounds 1-4 belong to the new 11(15-->1)-abeo-taxene system, having a tetrahydrofuran ring along carbons C-2, C-3, C-4 and C-20. Compounds 3 and 4 contain an isopropenyl group at C-1 while compounds 1 and 2 are attached with a benzoxyl group at C-15. The structures of compounds 1-5 were determined on the basis of two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY) experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bridged-Ring Compounds / chemistry
  • Bridged-Ring Compounds / isolation & purification*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Plant Roots / chemistry
  • Taiwan
  • Taxoids*
  • Taxus / chemistry*

Substances

  • Bridged-Ring Compounds
  • Diterpenes
  • Taxoids
  • taxumairol G
  • taxumairol H
  • taxumairol I
  • taxane